在免疫学杂志上发表的一项研究中,Southampton University researchers have shown that a new antibody that they have engineered is able to combine two different anticancer approaches: depleting regulatory T cells and activating killer T cells [1].摘要共刺激受体4-1bb在活化的免疫细胞上表达。including activated T cells.Antibodies…

Researchers at the University of Notre Dame discovered that amino acid nitration can inhibit the activation of T cells employed in immunotherapy against cancer and that suppression of reactive nitrogen species (RNS) responsible for nitration can significantly boost the effectiveness of immunotherapy [1].Abstract Potent immunosuppressive mechanisms within the tumor microenvironment contribute to the resistance…

Researchers at the Imperial College London have discovered that specifically employing invariant natural killer T cells,rather than generic T cells,in cancer immunotherapies based on chimeric antigen receptors might lead to significantly more effective,cheaper,and more easily mass-produced treatments [1].嵌合抗原受体抗CD19(car19)-T细胞免疫治疗诱导CD19+B临床缓解。

Led by Dr.Alicja Copik,中佛罗里达大学医学院的科学家们发现,通过使用PM21激活的自然杀伤细胞(PM21-NK),可以使癌症免疫疗法对大部分患者有效[1]。Study abstract Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited…

New research has identified the mechanisms responsible for enhancing immune system activity,提供更有效的癌症治疗和疫苗的新方法。Invariant natural killer T (iNKT) cells are part of the immune system's arsenal for fighting infection and defeating diseases like cancer.Finding ways to activate these potent cells more quickly could lead to…

哈佛大学的研究人员描述了一种新的癌症疫苗方法,该方法使用可注射的生物材料支架来传递肿瘤特异性肽的有效载荷,刺激免疫系统对癌细胞作出快速反应。Abstract Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration,which,beyond practical issues,可能会影响…

There may be other methods than drugs to destroy senescent cells,which accumulate with age.The immune system fails as we age,恢复活力可能是消除有害物质的另一条途径,pro-aging senescent cells.随着年龄的增长,衰老细胞和衰老药,increasing amounts of your cells enter into a state of senescence.Senescent…

Last year,我们谈到了一种新的癌症。”vaccine"currently in clinical trials in an article here,现在,由于实验室取得了令人印象深刻的结果,第二种癌症疫苗引起了媒体的兴趣。The new therapy is now in human clinical trials for lymphoma patients.Researchers at Stanford Medicine have found that injecting two…

Thirty-seven-year-old Nick Asoian of Denver unsuccessfully fought Hodgkin's Lymphoma using conventional cancer treatments for two years.In 2008,while in New Zealand for a ski race,Nick was diagnosed with the condition.两次骨髓移植和两年的化疗加上放射治疗并没有使他的癌症恶化。Nick Asoian.Image source:…

By now,the immunotherapeutic approach to fighting cancer has become so popular that you've most probably already heard of it—we've discussed it a few times too.虽然免疫疗法目前是我们抗癌武器库中最好的武器之一,it is not always effective;however,researchers at Zurich University have recently found a way to…

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